Here is a brief summary of the article: The article addresses the issue of weight gain after discontinuation of GLP-1 drugs used for weight loss. A systematic review shows that after discontinuation of GLP-1 therapy, patients gain an average of 0.4 kg per month and weight can return to baseline within two years. Obesity is a chronic disease, so long-term use of GLP-1 agonists should be considered, similar to the treatment of hypertension. Unanswered questions remain regarding when and how treatment should be discontinued and whether weight loss can be sustained. Observational studies suggest that a significant proportion of patients (46-65%) discontinue GLP-1 therapy.