The next director of the CDC (Centers for Disease Control and Prevention) will face extensive and immediate challenges. Among the main ones is the restoration of public trust in the institution after the COVID-19 pandemic. Another challenge is to modernize CDC's infrastructure and data systems for a more effective response to health crises. The director will also have to deal with workforce issues, including staff shortages and turnover. Improved communication with the public and transparency of decision-making processes will also be important. Other priorities include combating chronic diseases and addressing health care inequities. Last but not least, it is necessary to strengthen global health security and preparedness for future pandemics.