The study was concerned with the differentiation of lymphoma progression from benign lesions using PET/CT scans with [18F]FDG. They retrospectively analyzed 20 patients who developed new lesions during chemotherapy. They found that SUVmax and TBR (tumor-to-blood pool ratio) were significantly higher in cases of lymphoma progression. ROC analysis determined the optimal cut-off values for SUVmax (7.8) and TBR (13.78) for differentiating between lymphoma and benign lesions. These parameters can aid in the evaluation of treatment response and clinical decision-making. Age, gender, lymphoma type, disease stage, treatment phase, and lesion location were not significantly different between groups. The study suggests that SUVmax and TBR are valuable factors for differentiating between lymphoma and non-lymphoma lesions on PET/CT scans.