Angiography-based physiology is used to guide coronary revascularization. This method uses angiographic images to assess the functional significance of coronary lesions. The goal is to identify patients who would benefit the most from a revascularization procedure. The use of angiography-based physiology can help in deciding which lesions need to be treated. This technique aims to improve the clinical outcomes of patients with ischemic heart disease. Studies are investigating the effectiveness and safety of this method compared to traditional approaches. The results of these studies are published in the New England Journal of Medicine.