Dry eye is a disease that disrupts the balance of the tear film and affects the surface of the eye[1]. Perimenopausal women are at an extremely high risk for this disease, with the underlying cause being a disruption of sex hormones caused by ovarian failure[1]. A decrease in estrogen leads to a change in the function of the lacrimal glands and reduced eye hydration, while a decrease in androgens disrupts the formation of the fatty component of the tear film, causing its instability[1]. In addition to hormonal changes, chronic immune inflammatory response, neuroendocrine changes, perimenopausal depression, sleep disorders and the use of hormone replacement therapy also contribute to the risk of the disease[1]. Symptoms of dry eye include burning, cutting, redness, blurred vision, and sometimes excessive tearing as a compensatory mechanism[1]. Research has confirmed that approximately 79% of menopausal and postmenopausal women experience symptoms of dry eye syndrome, with sensitivity to light being the most common symptom[1]. Due to the complexity of risk factors, individualized approaches to the prevention and treatment of dry eye in perimenopausal women are needed[1].