The study evaluated the safety and efficacy of a new device called a double-clip across the scope (TTS-TC) for endoscopic closure of defects in the alimentary canal. A retrospective observational study included 36 patients (22 men and 14 women) with a mean age of 61 years who underwent the procedure between February and December 2023. The majority of procedures were performed in the stomach (61.1%), with indications including stopping ulcer bleeding, closing perforations, and treating deep wall lesions. Successful device placement was achieved in all 36 patients, with a mean procedure time of 3.5 minutes and a mean lesion size of 3.5 cm. The average length of hospitalization after the procedure was 5.7 days. Patients who underwent full-thickness resection had more adverse events, including intraprocedural perforation, abdominal pain, and fever, compared with other patients. The study reported no adverse events directly related to the clip itself, suggesting that the TTS-TC is a promising tool for the closure of various gastrointestinal defects.