This is an erratum to the report entitled "Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations". The report was published in Science, Volume 333, Number 6051, September 30, 2011. Erratum was published in Science, Volume 391, Number 6788, February 26, 2026. The original report shows that chromosome segregation errors during mitosis cause structural chromosome aberrations such as translocations and deletions. Missegregating chromosomes are damaged during cytokinesis, triggering a DNA double-strand break response involving the proteins ATM, Chk2, and p53. These breaks lead to unbalanced translocations in the daughter cells. In MCF7 and SW480 tumor cell lines, the number of 53BP1 foci increased from an average of 0.3 to 1 or 0.7 to 1.5 after segregation errors. Approximately 70% of the 53BP1 targets disappeared within 8 h, suggesting fragment repair or fusion.[3][1][2]