The article describes the molecular framework for the integration of root and shoot responses to nitrogen in plants. The root, as the main sensor of nitrogen availability, coordinates shoot growth and development through cytokinins. Upon nitrogen supply, NLP7, the main regulator of nitrogen response, is activated in roots and promotes the synthesis of cytokinins and their transport to shoots[1][6]. In shoots, cytokinin response factors (CRFs), transcription factors of the APETALA2/ERF type, regulate development according to the level of cytokinins[1]. This mechanism enables the rapid adjustment of shoot growth according to the state of nitrogen in the soil[1][6]. The root-shoot integration model understands the efficiency of nitrogen use as a system property of the plant, not a property of a single organ[6]. Experiments have shown rapid activation of genes such as HRS1 and TGA1 in roots within 1 hour of nitrogen addition[1]. This framework provides a basis for understanding plant adaptation to nitrogen changes[1][6].