According to a study published in MedPage Today, most people surveyed are unwilling to use statins for primary prevention at their actual level of effectiveness. The study has implications for patient-physician shared decision-making. When informed about possible adverse events, people claim that statins are more effective than they actually are. Primary prevention focuses on people without a diagnosed cardiovascular disease, but with a high risk of developing it. Statins lower LDL cholesterol by inhibiting an enzyme in the liver. The decision on their use should be individualized based on risk factors.