Advancing the diagnosis of cardiac electrophysiological disorders in diabetes: integrating clinical, imaging, and molecular insights

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Source: Frontiers Medicine

Original: https://www.frontiersin.org/articles/10.3389/fmed.2026.1777638...

Published: 2026-02-03T00:00:00Z

Diabetes mellitus is a systemic metabolic disorder associated with an increased risk of cardiac electrophysiological abnormalities such as atrial and ventricular arrhythmias, conduction disturbances, and autonomic dysfunction. These complications contribute significantly to morbidity and mortality, but are often underrecognized due to the limitations of traditional methods such as surface electrocardiography and intermittent monitoring. Electrophysiological instability in diabetes arises from the interaction of metabolic dysregulation, microvascular damage, inflammation, and molecular changes that are not fully captured by traditional electrical assessments. Recent advances in cardiovascular imaging, molecular diagnostics, and artificial intelligence analytics allow better detection, risk stratification, and characterization of these disorders. The article highlights the shortcomings of existing diagnostic approaches and explores innovations integrating clinical assessment with advanced imaging and molecular insights. It proposes an integrative framework using multimodal data and digital technologies to identify high-risk patients earlier and support precision cardiology practices. These strategies can improve clinical decision-making, personalized management and reduce the burden of electrophysiological complications in diabetics.