A 50-year-old man with a 10-year history of hypertension treated with metoprolol and chronic kidney disease on long-term hemodialysis presented with two weeks of pruritic erythema and blisters on the trunk that progressed rapidly over the body. Physical examination showed extensive tense blisters and bullae on an erythematous background, while Nikolsky's sign was negative. Direct immunofluorescence revealed linear deposition of IgG in the basement membrane zone, and serology was strongly positive for anti-BP180 IgG antibodies. He was diagnosed with bullous pemphigoid, a chronic blistering skin disease caused by autoantibodies against the dermal-epidermal junction. Renal insufficiency and hemodialysis are risk factors for its development, with reported triggers such as dialysis materials, medications, transplant rejection, and immune dysregulation in CKD. The patient's medications have not been changed recently.