A network meta-analysis investigated induction strategies to prevent hemodynamic changes after tracheal intubation in patients undergoing non-cardiac surgery. It included 10 randomized controlled trials with 791 patients. The main indicators were changes in mean arterial pressure (ΔMAP) and heart rate (ΔHR). The oxycodone-propofol-lidocaine combination (87.4%) was most effective in controlling MAP fluctuations, followed by fentanyl-propofol-dexmedetomidine (82.9%) and fentanyl-propofol-clonidine (81.6%). Fentanyl-propofol-dexmedetomidine (94.8%), followed by fentanyl-propofol-lidocaine (epidural) (83.3%) and fentanyl-propofol-remifentanil (79.1%) were the best in controlling HR fluctuations. The study recommends further randomized controlled trials to confirm the results and optimal dosing. Registration: CRD42024591333.