Brief, factual summary in Slovak: The APPAC study monitored the 10-year results of treatment of uncomplicated acute appendicitis with antibiotics versus surgery. The results showed that antibiotic treatment was successful in most patients and had a lower risk of complications compared to surgery. The next article provides an overview of restless legs syndrome, including symptoms, diagnosis, and treatment. The editorial comment discusses the dilemma of whether to prefer operative or conservative management of appendicitis. Additional articles address the management of opioid use disorders and the prediction of platelet transfusion outcomes in preterm infants. The summary also includes information on the latest trends and guidelines in medicine, such as the use of artificial intelligence.