Effects of continuous versus intermittent enteral feeding on feeding tolerance in critically ill adults: a systematic review and meta-analysis

Back to news list

Source: Frontiers Medicine

Original: https://www.frontiersin.org/articles/10.3389/fmed.2026.1738036...

Published: 2026-01-21T00:00:00Z

The study compared continuous and intermittent enteral feeding in critically ill patients and analyzed 17 randomized controlled trials. The main finding was that continuous enteral nutrition was associated with an increased risk of constipation (RR = 1.40), with this risk being particularly elevated in short-term interventions lasting less than 7 days (RR = 2.55). There were no statistically significant differences in diarrhea, vomiting, residual gastric volume, abdominal distension, aspiration, ICU mortality, or length of stay between the two feeding regimens. The authors of the study point out that the included studies carried some risk of bias and the overall certainty of the evidence was low or very low according to the GRADE approach. Due to the low quality of evidence and small sample sizes, the conclusions are advised to be interpreted with caution. Future large-scale, high-quality studies with long-term follow-up are needed to confirm the efficacy of intermittent enteral feeding.