The ongoing global health crisis presents an opportunity to transform the fragmented global health architecture. The article issues an urgent call for coordinated action - a global health leap. It calls for all stakeholders to unite around a common scope, clear goals and principles, and a process of transformational change. Over the past 50 years, major emergencies such as HIV/AIDS, SARS, Ebola and COVID-19 have led to the expansion of the global health architecture. These crises, along with optimism about the Millennium Development Goals and multilateralism, contributed to the expansion of the system.[2][3]