The article looks at how doctors can help patients with chronic lymphocytic leukemia (CLL) manage the fear and uncertainty associated with the diagnosis and the long-term course of the disease. It emphasizes the importance of empathetic, open and understandable communication between doctor and patient, especially when explaining the nature of CLL, monitoring and treatment options. He describes that patients often struggle with fears about the future, the progression of the disease and the need to start treatment. The need for doctors to actively find out what the patient understands, what questions he has and what information he needs at a given moment is discussed. Supporting patients in making treatment decisions and coping with the "watch and wait" period when treatment has not yet started is also an important topic. The article also points to the benefit of a multidisciplinary approach and the involvement of family or support groups in reducing the psychological burden of patients with CLL. The central message is that quality communication and understanding between doctor and patient are key to better managing fear and uncertainty in this chronic oncological disease.