The study addresses the treatment of stage 2 pressure injuries in China, where they are often treated by general nurses without wound specialization and management is therefore often inadequate. The aim was to gather the best available evidence on the management of these wounds and to develop a standardized, evidence-based nursing protocol for clinical practice. A continuous quality improvement model with four phases (evidence collection, baseline review, evidence implementation, effectiveness evaluation) was used in a tertiary care hospital, involving 80 skin nurses and 70 stage 2 PI patients. After the introduction of the protocol, the nurses' knowledge (PZ-PUKT score) significantly improved from 53.31 ± 4.75 to 56.29 ± 4.02 points. The rate of fulfillment of key quality indicators also increased significantly, with some indicators increasing from 0% to 100%. Patients in the intervention group showed a significant reduction in PUSH scores, a reduction in VAS pain intensity, and a higher rate of wound healing (all p < 0.05). The authors report that such a structured approach provides a feasible model for standardized care of stage 2 pressure injuries in resource-limited settings and can serve as a basis for further multicenter research.