The study describes the development and evaluation of a blended learning ultrasound course for healthcare professionals that combined asynchronous e-learning modules with high-fidelity simulation. The course was created gradually on the basis of needs assessment, repeated revision of the curriculum and several cycles of implementation and evaluation. Learning success was assessed using performance in online modules, pre- and post-course tests, and subgroup analysis of participants who completed the entire curriculum. Participants achieved a statistically significant improvement in knowledge after the intervention with a mean score increase of 10.24% (p = 0.0033). The lung and eye ultrasound modules had high scores and low variability, indicating that their educational design was effective. Subgroup analysis confirmed that full completion of all parts of the course was associated with better and more consistent performance. The cardiac ultrasound module had a lower average performance and high variability, so it was recommended to redesign it with a focus on better "scaffolding" (gradual guidance) of the curriculum. The authors conclude that a design-based approach enabled systematic alignment of educational strategies with student needs and the creation of a scalable model of ultrasound education integrated with simulation.