The article discusses the potential of ginseng ginsenosides as promising antitumor agents targeting hypoxia-inducible factor-1α (HIF-1α). HIF-1α is a key transcriptional regulator that allows tumor cells to adapt to a lack of oxygen and affects tumor proliferation, growth, new vessel formation (angiogenesis) and metastasis. High expression of HIF-1α is associated with poor prognosis in patients with multiple solid tumors. Pharmacological targeting of HIF-1α is presented in the article as a promising therapeutic strategy for cancer treatment. The review presents ginseng, or more precisely its ginsenosides, as HIF-1α inhibitors that can suppress tumor development in experiments in vitro (in cell cultures) and in vivo (in animal models). The authors emphasize the need for a more detailed analysis of the molecular mechanisms by which ginseng affects cancer cells through HIF-1α. The results presented in the review are intended to help clarify the relationship between HIF-1α and ginseng in antitumor therapy.