Weight loss and cardiometabolic benefits were fully reversed within 2 years in overweight or obese people who stopped taking weight management drugs. This was shown by a systematic review and meta-analysis published on MedPage Today. The study included adult patients who had discontinued treatment. After stopping the medication, there was a complete return to the original health conditions. Benefits have included improvements in cardiovascular and metabolic health while on medication. The results emphasize that maintenance of benefits requires long-term treatment.