The U.S. government has signed new health agreements with at least nine African countries, including Rwanda, reflecting the Trump administration's priorities.1 These agreements represent a new approach to global health financing, with an emphasis on effective systems management and country self-sufficiency.1[4] A $228 million agreement has been reached with Rwanda to support its health system.[Of that, the U.S. will provide up to $158 million to fight HIV and AIDS.1 The agreement has a comprehensive vision to save lives, strengthen the system, and make the U.S. safer.1 Rwanda is the second country, after Kenya, with which the U.S. has signed such an agreement since Trump's return.1 The head of Rwanda's MFA called the agreement evidence of Rwanda's ambition to build a self-sustaining and technology-supported health system.1 The strategy was unveiled in September 2025.[1] The U.S.