A cross-sectional study evaluated the long-term symptoms and functional status of Long COVID in 220 patients with a clinically confirmed diagnosis. The average age of the participants was 44.8 years and 80.5% were women. Data were collected through an electronic form on sociodemographic, clinical and lifestyle data, functional limitations were assessed with the PCFS scale. A higher number of symptoms was associated with worse PCFS grades in the adjusted model (β = 0.17; 95% CI 0.10–0.25; p < 0.001). Independent predictors of greater limitations were fatigue (crude β 1.56; 95% CI 1.22–1.90), dizziness (β 1.08; 95% CI 0.81–1.34) and memory loss (β 1.26; 95% CI 0.95–1.57). These factors explained 51.3% of the variance in functional limitations, other symptoms lost their independent association after adjustment. The findings support the use of symptom counts and targeted profiles for risk stratification in primary care, rehabilitation and work capacity assessment.