Obesity significantly accelerates the progression of Alzheimer's disease by increasing levels of blood biomarkers associated with neurodegeneration and amyloid formation. Long-term follow-up using imaging methods and plasma analysis has shown that obese individuals experience a faster increase in these proteins compared to people of normal weight. Blood tests can detect these changes earlier than PET scans, suggesting their potential as early indicators of disease. Research confirms that obesity is a significant modifiable risk factor for faster deterioration of Alzheimer's disease. Additionally, obesity is associated with brain inflammation, metabolic stress, and lower choline levels, which may contribute to brain cell damage at a young age. These findings highlight the importance of controlling body weight to prevent or slow the progression of Alzheimer's disease.