A retrospective study evaluated 339 patients in palliative care and found that the prevalence of pressure ulcers was 33.6%, with 385 ulcers recorded in 114 patients. The most common type of pressure ulcer was deep tissue injury (26%). Significant independent risk factors included stroke, gastrointestinal disease, paraplegia, recent confusion, hypertension, coronary artery disease, arrhythmia, and heart failure. A longer hospital stay also increased the risk of pressure ulcers. On the contrary, adherence to prevention protocols and complete dependence on care were protective factors against the development of pressure ulcers. The authors emphasize the need for targeted preventive measures aimed at cardiovascular and neurological stability, nutritional support and strict adherence to care protocols. A multidisciplinary and individualized approach should be part of the routine management of patients in palliative care to reduce pressure ulcer burden and improve treatment outcomes.