Schimmelpenning-Feuerstein-Mims syndrome (SFMS) is a rare genetic disorder characterized by the presence of linear sebaceous nevi and a wide spectrum of abnormalities, including ocular, neural, skeletal, and cardiovascular abnormalities. The main cause is postzygotic mutations in the genes of the RAS pathway: HRAS, KRAS and NRAS. A systematic review identified 50 patients with genetically confirmed mutations, with 17 having HRAS, 30 KRAS and 3 NRAS mutations. Patients with KRAS mutations more frequently showed ocular and central nervous system abnormalities, while HRAS mutations were associated with skeletal abnormalities (p < 0.05). The incidence of benign and malignant tumors was similar in both groups, but kidney tumors were strongly associated with KRAS mutations. The authors emphasize the need for genetic testing in all suspected patients for better risk determination and personalized follow-up. The review included literature from 1946 to 2025 without language or age restrictions[source].